000			02641 a2200241 4500
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020			_a9780691220635
082			_a612.8 RAM
100			_aRaman, Indira M.
245			_aAnnotated Hodgkin and Huxley: a reader's guide
260			_aNew Jersey: _bPrinceton University Press, _c2021.
300			_axi, 311p.: _bill.; pbk.: _c24cm.
504			_aIncludes References and Index
520			_aThe origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley’s rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing. This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding the work. The original journal pages are displayed opposite detailed notes explaining content, process, and background, with copies of the figures replotted according to modern conventions. Indispensable for scientists, teachers, and trainees alike, The Annotated Hodgkin and Huxley makes an essential body of knowledge—and an unparalleled approach to research—accessible to a new generation of readers. Reproduces the original articles paired with extensive annotations on facing pages Replots figures with modern conventions of data display Explains the development of the voltage clamp and the discovery of ionic currents and action potential generation, foundational to the study of neuroscience and physiology Summarizes the history of electrophysiology leading to Hodgkin and Huxley’s work Includes appendices on relevant concepts from mathematics, physics, electronics, chemical kinetics, and numerical methods https://press.princeton.edu/books/paperback/9780691220635/the-annotated-hodgkin-and-huxley?srsltid=AfmBOoonGeVmhGlyg0VKaFIUvET7DFLPzdc_8-uQ8FooCRZgArCXa3SF
650			_aNeurophysiology
650			_aNeuroscience
650			_aLife Sciences
650			_aScientific Papers on Neuroscience
650			_aBiophysics
650			_aPhysiology
700			_aFerster, David L. _eCo-author
942			_cTD _2ddc
999			_c61547 _d61547