TY - GEN AU - Glaeser, Robert M. (Ed.) AU - Nogales, Eva AU - Chiu,Wah TI - Single-particle Cryo-EM of Biological macromolecules SN - 9780750330374 U1 - 574.19283 PY - 2021/// CY - London PB - IOP publishing KW - Molecular biology KW - 3D reconstruction KW - Biophysics KW - Cryo-EM KW - High resolution imaging KW - Cryo-EM-structure N1 - includes References N2 - This edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. Furthermore, it is especially well suited for larger complexes and molecular machines, although it can also be used for macromolecules as small as 40 kDa or less. It also is especially well-suited to deliver high-resolution structural information about multiple conformational states. https://store.ioppublishing.org/page/detail/Singleparticle-CryoEM-of-Biological-Macromolecules/?k=9780750330374 ER -